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Recent Publications

Peter Meissner

  1. Pandie M; Sonderup M, Meissner PN, Mendelson M. 
    Acute porphyria precipitated by nevirapine. 
    AIDS, 2010 24(16): 2597 - 2599
  2. Corrigall AV, Campbell JAH, Siziba K, Kirsch RE, Meissner PN.
    The Expression of Protoporphyrinogen Oxidase in human tissues.
    Cellular and Molecular Biology, 2009, 55(2): 89 - 95

Arieh Katz

  1. Abera AB, Sales KJ, Catalano RD, Katz AA, Jabbour HN.
    EP2 receptor mediated cAMP release is augmented by PGF2a activation of the FP receptor via the calcium-calmodulin pathway. 
    Cellular Signalling, 2010, 22: 71 - 79.
  2. Folefoc AT, Fromme BJ, Katz AA, Flanagan CA. 
    South African Mutations of the CCR5 Coreceptor for HIV Modify Interaction With Chemokines and HIV Envelope Protein. 
    Journal of Acquired Immune Deficiency Syndromes, 2010, 54(4): 352 - 359.
  3. Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM. 
    Filamin A Binds to CCR2B and Regulates Its Internalization. 
    PLoS ONE, 2010, 5(8): e12212 1 - 14.
  4. Stewart AJ, Katz AA, Millar RP, Morgan K.
    Retention and Silencing of Prepro-GnRH-II and Type II GnRH Receptor Genes in Mammals.
    Neuroendocrinology, 2009, 90: 416 - 432
  5. Fromme BJ, Coetsee M, Van Der Watt P, Chan MC, Sperling KM, Katz AA, Flanagan CA.
    High-affinity binding of southern African HIV type 1 subtype C envelope protein, gp120, to the CCR5 coreceptor. 
    AIDS Res Hum Retroviruses. 2008 Dec;24(12):1527-36.

Robert (Bob) Millar

  1. Millar RP, Roseweir AK, Tello JA, Anderson RA, George JT, Morgan K, Pawson AJ.
    Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology. 
    Brain Research 1364, 2010, 81 - 89.
  2. Teixeira L, Guimiot F, Dodé C, Fallet-Bianco C, Millar RP, Delezoide AL, Hardelin JP. 
    Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions. 
    The Journal of Clinical Investigation, 2010, 120(10): 3668 - 3672.
  3. Ramaesh T, Logie JJ, Roseweir AK, Millar RP, Walker BR, Hadoke PWF, Reynolds RM. 
    Kisspeptin-10 Inhibits Angiogenesis in Human Placental Vessels ex Vivo and Endothelial Cells in Vitro. 
    Endocrinology, 2010, 151(12): 5927 - 5934.
  4. Millar RP, Newton CL. 
    The Year in G Protein-Coupled Receptor Research. 
    Molecular Endocrinology, 2010, 24(1): 261 - 274.
  5. George JT, Millar RP, Anderson RA. 
    Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes. 
    Neuroendocrinology, 2010, 91: 302 - 307.
  6. Ukuba T, Morgan K, Pawson AJ, Osugi T, Chowdhury VS, Minakata H, Tsutsui K, Millar RP, Bentley GE.
    Identification of Human GnIH Homologs, RFRP-1 and RFRP-3, and the Cognate Receptor, GPR147 in the human Hypothalmic Pituitary Axis.
    PLoS ONE, 2009, 4(12): e8400 1 - 7.
  7. Li XF, Kinsey-Jones JS, Cheng Y, Knox AMI, Lin Y, Petrou NA, Roseweir AK, Lightman SL, Milligan SR, Millar RP, O'Byrne KT.
    Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat
    PLoS ONE, 2009, 4(12): e8334 1 - 9
  8. Joseph NT, Morgan K, Sellar R, McBride D, Millar RP, Dunn IC.
    The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor. 
    Journal of Endocrinology, 2009, 202: 179 - 190.
  9. Reynolds RM, Logie JJ, Roseweir AK, McKnight AJ, Millar RP.
    A role of kisspeptins in pregnancy: facts and speculations
    Reproduction, 2009, 138: 1 - 7.
  10. Bouligand J, Ghervan C, Tello JA, Brailly-Tabard S, Salenave S, Chanson P, Lombès M, Millar RP, Guiochon-Mantel A, Young J.
    Isolated Familial Hypogonadotropic Hypogonadism and a GNRH1 Mutation.
    New England Journal of Medicine, 2009, 360(26): 2742 - 2748
  11. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP.
    Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation.
    Journal of Neuroscience, 2009, 29(12): 3920 - 3929
  12. Roseweir AK, Millar RP.
    The role of kisspeptin in the control of gonadotrophin secretion.
    Human Reproduction Update, 2009, 15(2): 203 - 212
  13. White CD, Coetsee M, Morgan K, Flanagan CA, Millar RP, Lu ZL.
    A crucial role for Galphaq/11, but not Galphai/o or Galphas, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition.
    Mol Endocrinol. 2008 Nov;22(11):2520-30. Epub 2008 Sep 18.
  14. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE.
    Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.
    Endocrinology. 2008 Nov;149(11):5811-21. Epub 2008 Jul 10.
  15. Coetsee M, Millar RP, Flanagan CA, Lu ZL
    Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation.
    Biochemistry. 2008 Sep 30;47(39):10305-13. Epub 2008 Sep 5.
  16. Stewart AJ, Sellar R, Wilson DJ, Millar RP, Lu ZL
    Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor.
    Mol Pharmacol. 2008 Jan;73(1):75-81. Epub 2007 Oct 17
  17. Roseweir AK, Millar RP.
    The role of kisspeptin in the control of gonadotrophin secretion.
    Hum Reprod Update. 2009 Mar-Apr;15(2):203-12. Epub 2008 Dec 24

Denver Hendricks

  1. Chellan P, Shunmoogam-Gounden N, Hendricks DT, Gut J, Rosenthal PJ, Lategan C, Smith PJ, Chibale K, Smith GS. 
    Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents. 
    European Journal of Inorganic Chemistry, 2010, 3520 - 3528.
  2. Van Der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
    The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
    International Journal of Cancer, 2009, 124: 1829 - 1840
  3. Stringer T, Chellan P, Therrien B, Shunmoogam-Gounden N, Hendricks DT, Smith GS.
    Synthesis and structural characterization of binuclear palladium(II) complexes of salicylaldimine dithiosemicarbazones
    Polyhedron, 2009, 28: 2839 - 2846
  4. Van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
    The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
    Int J Cancer. 2008 Nov 11. [Epub ahead of print]
  5. van Wyk AW, Gray CA, Whibley CE, Osoniyi O, Hendricks DT, Caira MR, Davies-Coleman MT.
    Bioactive metabolites from the South African marine mollusk Trimusculus costatus.
    J Nat Prod. 2008 Mar;71(3):420-5. Epub 2008 Feb 21.

Virna Leaner

  1. Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ. 
    Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis Murine Osteosarcoma.
    American Journal of Pathology, 2009, 174(01): 265 - 275
  2. Calvisi DF, Donninger H, Vos MD, Birrer MJ, Gordon L, Leaner VD, Clark GJ.
    NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53.
    Cancer Research, 2009, 69(11): 4629 - 4637.
  3. Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ.
    Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.
    Am J Pathol. 2009 Jan;174(1):265-75. Epub 2008 Dec 12.
  4. Copley L, van der Watt P, Wirtz KW, Parker MI, Leaner VD.
    Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis. 
    Int J Biochem Cell Biol. 2008;40(2):227-35. Epub 2007 Aug 1

Iqbal Parker

  1. Abrahaams A, Parker MI, Prince S. 
    The T-box Transcription Factor Tbx2: Its Role in Development and Possible Implication in Cancer. 
    IUBMB Life, 2010, 62(2): 92 - 102.
  2. Kaschula CH, Hunter R, MI Parker
    Garlic-derived anticancer agents: Structure and biological activity of ajoene
    Biofactors, 2010, 36(1) 78 - 85.
  3. Li D, Dandara C, Parker MI. 
    The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. 
    BMC Genetics, 2010, 11(47): 1 - 9.
  4. Wang B, Khachigian LM, Esau L, Birrer MJ, Zhao X, Parker MI, Hendricks DT.
    A Key Role for Early Growth Response-1 and Nuclear Factor-kB in Mediating and Maintaining GRO/CXCR2 Proliferative Signalling in Esophageal Cancer.
    Molecular Cancer Research, 2009, 7(5): 755 - 764
  5. Torniainen S, Parker MI, Holmberg V, Lahtela E, Dandara C, Jarvela I.
    Screening of Variants for lactase persistence/non-persistence in populations from South Africa and Ghana. 
    BioMed Central Genetics, 2009 July 5th doi:10.1186/1471-2156/10/31
    (Online journal - no page numbers, volumes etc.)
  6. Teng H, Parker MI, Prince S.
    Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene: a new insight into the role of Sp1 in transcriptional regulation.
    Gene. 2008 Oct 15;423(1):8-13. Epub 2008 Jun 21.
  7. Li DP, Dandara C, Walther G, Parker MI 
    Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer.
    Clin Chem Lab Med. 2008;46(3):323-8.
  8. Donninger H, Binder A, Bohm L, Parker MI.
    Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells.
    Biol Chem. 2008 Jan;389(1):57-67.
  9. Abrahams A, Mowla S, Parker MI, Goding CR, Prince S
    UV-mediated regulation of the anti-senescence factor Tbx2.
    J Biol Chem. 2008 Jan 25;283(4):2223-30. Epub 2007 Nov 19.

Trevor Sewell

  1. Williamson DS, Dent KC, Weber BW, Varsani A, Frederick J, Thuku RN, Cameron RA, van Heerden JH, Cowan DA, Sewell BT.
    Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8.
    Applied Microbiology and Biotechnology, 2010, 88: 143 - 153.
  2. Petersen LN, Marineo S, Mandalà S, Davids F, Sewell BT, Ingle RA.
    The Missing Link in Plant Histidine Biosynthesis: Arabidopsis myoinositol monophosphatase-like2 Encodes a Functional Histidinol-Phosphate Phosphatase1[W] [OA] . 
    Plant Physiology, 2010, 152: 1186 - 1196.
  3. van Rooyen JM, Abratt VR, Belrhali H, Sewell BT. 
    Crystallization of recombinant Bacteroides fragilis glutamine synthetase (GInN) isolated using a novel and rapid purification protocol. 
    Protein Expression and Purification, 2010, 74: 211 - 216.
  4. Joubert MK, Kinsley N, Capovilla A, Sewell BT, Jaffer MA, Khati M.
    A Modeled Structure of an Aptamer-gp120 Complex Provides Insight into the Mechanism of HIV-1 Neutralization. 
    Biochemistry, 2010, 49: 5880 - 5890.
  5. Gildenhuys S, Dobreva M, Kinsley N, Sayes Y, Burke J, Pelly S, Gordon GP, Sayed M, Sewell BT, Dirr HW. 
    Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1. 
    Biophysical Chemistry, 2010, 146: 118 - 125.
  6. Opperman DJ, Sewell BT, Litthauer D, Isupov MN, Littlechild JA, van Heerden E. 
    Crystal structure of a themostable Old Yellow Enzyme from Thermus scotoductus SA-01. 
    Biochemical and Biophysical Research Communications, 2010, 393: 426 - 431.
  7. Woodward JD, Sewell BT. 
    Tomography of asymmetric bulk specimens imaged by scanning electron microscopy. 
    Ultramicroscopy, 2010, 110: 170 - 175.
  8. Achilonu I, Gildenhuys S, Fisher L, Burke J, Fanucchi S, Sewell BT, Fernandes M, Dirr HW. 
    The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function. 
    Acta Crystallographica Section F, 2010, F66: 776 - 780.

Lutz Thilo

  1. de Chastellier C, Forquet F, Gordon A, Thilo L. 
    Mycobacterium requires an all-around closely apposing phagosome membrane to maintain the maturation block and this apposition is re-established when it rescues itself from phagolysosomes.
    Cellular Microbiology, 2009, 11(08): 1190 - 1207

Cynthia Sikakhana

  1. Sikakhana, CNT. 
    Supporting student-doctors from under-resourced educational backgrounds: an academic development programme. 
    Medical Education, 2010, 44: 917 - 925.